Urea permeability of lipid bilayer membranes made from red cells (see 'Comments' for more values)

Value 5.7E-07 cm/sec
Organism Human Homo sapiens
Reference Wood RE, Wirth FP Jr, Morgan HE. Glucose permeability of lipid bilayer membranes. Biochim Biophys Acta. 1968 Sep 17 163(2):171-8. Abstract & (additional values in 'Comments' section:) p.175 3rd paragraphPubMed ID5686274
Primary Source [17] T. E. Thompson, personal communication, quoted in T. Hanai and D. A. Haydon, The permeability to water of bimolecular lipid membranes., J Theor Biol. 1966 Aug11(3):370-82. [9] HJ Vreeman, Permeability of thin phospholipid films, Konink. Ned. Akad. Wetenschap. Proc., Ser. B, 69 (1966) 542PubMed ID5967438
Method "Bimolecular lipid membranes have been prepared from total phospholipid extracts of human red cells. The electrical properties and water permeability of these membranes were similar to values reported earlier for other bilayer membranes."
Comments "The urea permeability coefficient was 5.7X10^-7 cm/sec...Urea permeability of 1O membranes was estimated with [14C]urea (50 mC/mmole). The low permeability required the use of high concentrations in the donor chamber, usually about 5X10^7 counts/min per ml. k[urea] averaged 5.9X10^-7±0.3X10^-7cm/sec. Corresponding values reported for other bilayer membranes are 3X10^-6cm/sec [primary source 17] and 4.2X10^-6cm/sec [primary source 9]."
Entered by Uri M
ID 110828