Comparison of hepatic glucose metabolism model predictions and experiments

Range Table - link
Organism Human Homo sapiens
Reference Konig M, Bulik S, Holzhütter HG. 2012. Quantifying the contribution of the liver to glucose homeostasis: a detailed kinetic model of human hepatic glucose metabolism. PLOS Computational Biology 8:e1002577. doi:10.1371/journal.pcbi.1002577. p.7 table 3PubMed ID22761565
Primary Source See pointers to refs on right of table
Comments "[Researchers] present the first detailed kinetic model of human hepatic glucose metabolism integrated with the hormonal regulation via insulin, glucagon and epinephrine (Figure 1 and Methods) via a new concept of changes in phosphorylation state (Figure 2 and Methods). The model was validated with quantitative and qualitative experimental data from a multitude of studies on hepatic glucose metabolism in overnight fasting, short term fasting and postprandial glycogen storage (Table 3, Figure 3, Figure 4, Dataset S1)."
Entered by Uri M
ID 110780