Number of active stem cells in each intestinal compartment

Range 4 - 6 active stem cells/compartment
Organism Mouse Mus musculus
Reference Frank SA, Nowak MA. Problems of somatic mutation and cancer. Bioessays. 2004 Mar26(3):291-9. p.292 left column 5th paragraphPubMed ID14988930
Primary Source Marshman E, Booth C, Potten CS. 2002. The intestinal epithelial stem cell. BioEssays 24: 91–98.PubMed ID11782954
Comments "Little is known about the history of stem lineages. For example, how many actively dividing stem cells renew a compartment? This remains controversial. Potten’s group estimated 4–6 active stem cells in each mouse intestinal compartment (primary source) other estimates range from one stem cell to more than half of all cells in a compartment."
Entered by Uri M
ID 110646