Number of lymphoid follicles in the large intestine

Range ~12,000–18,000 follicles /large intestine
Organism Human Homo sapiens
Reference McConnell EL, Basit AW, Murdan S. Measurements of rat and mouse gastrointestinal pH, fluid and lymphoid tissue, and implications for in-vivo experiments. J Pharm Pharmacol. 2008 Jan60(1):63-70. p.64 left column bottom paragraphPubMed ID18088506
Primary Source Langman, J. M, Rowland, R. (1986) The number and distribution of lymphoid follicles in the human large intestine. J. Anat. 149: 189–194 & Langman, J. M., Rowland, R. (1992) Density of lymphoid follicles in the rectum and at the anorectal junction. J. Clin. Gastroenterol. 14: 81–84 & Gebbers, J. O., Kennel, I., Laissue, J. A. (1992) Lymphoid follicles of the human large bowel mucosa: structures and function. Verh. Dtsch. Ges. Pathol. 76: 126–130PubMed ID3693106, 1556415, 1283242
Comments "Like the small intestine, the colon contains gut-associated lymphoid tissue. In man, there are approximately 339 Peyer’s patches (Cornes 1965 BNID 110511) in the small intestine, and approximately 12,000–18,000 follicles in the large intestine (primary sources). Presence of such a large number of follicles in man’s colon implies the feasibility of vaccine uptake and processing in the colon."
Entered by Uri M
ID 110512