Mutant frequency in brain

Range young mice 4.8e-5 old mice 5.0e-5 mutant frequency (uncertain units ?)
Organism Mouse Mus musculus
Reference Busuttil RA, Garcia AM, Reddick RL, Dollé ME, Calder RB, Nelson JF, Vijg J. Intra-organ variation in age-related mutation accumulation in the mouse. PLoS One. 2007 Sep 12 2(9):e876. p.1 left column 2nd paragraphPubMed ID17849005
Primary Source Dolle´ ME, Giese H, Hopkins CL, Martus HJ, Hausdorff JM, et al. (1997) Rapid accumulation of genome rearrangements in liver but not in brain of old mice. Nat Genet 17: 431–434.PubMed ID9398844
Method "Using transgenic mice harboring a chromosomally integrated lacZ reporter gene"
Comments "Interestingly, the small intestine, a tissue with a very high cell proliferative activity, was found to undergo the largest age-related increase in mutant frequency among all organs studied, i.e., from 11.0X10^-5 in young mice to 25.6X10^-5 in old mice [BNID 110457]. By contrast, in brain, a postmitotic organ, there was virtually no such age-related increase, i.e., from 4.8X10^-5 in young animals to 5.0X10^-5 in old ones [primary source]." "age group: 3–8 months (young), 16–21 months (middle), and 25–34 months (old)."
Entered by Uri M
ID 110458