Number of partial reaction steps in overall reaction of cyclosporin synthesis
| Range | ≥40 reaction steps/synthesis |
|---|---|
| Organism | Fungus Tolypocladium inflatum (Beauveria nivea) |
| Reference | Lawen A, Zocher R. Cyclosporin synthetase. The most complex peptide synthesizing multienzyme polypeptide so far described. J Biol Chem. 1990 Jul 5 265(19):11355-60. p.11360 left column 3rd paragraphPubMed ID2358465 |
| Method | "The overall reaction of cyclosporin synthesis can be divided in at least 40 partial reaction steps: 11 aminoadenylation reactions, 11 transthiolation reactions, 7 N-methylation reactions, 10 elongation reactions, and the final cyclization reaction. Possible other transthiolation reactions from one thiol group to another are not included in this calculation." |
| Entered by | Uri M |
| ID | 110415 |