Number of B cells in lymphocyte population

Value 1e+11 B-cells/single individual’s lymphocyte population
Organism Human Homo sapiens
Reference Glanville J, Zhai W, Berka J, Telman D, Huerta G, Mehta GR, et al. Precise determination of the diversity of a combinatorial antibody library gives insight into the human immunoglobulin repertoire. Proc Natl Acad Sci U S A 2009 106:20216-21. doi: 10.1073/pnas.0909775106. p.20216 left column bottom paragraphPubMed ID19875695
Primary Source Perelson AS, Oster GF (1979) Theoretical studies of clonal selection: Minimal antibody repertoire size and reliability of self-non-self discrimination. J Theor Biol 81: 645–670. & Trepel F (1974) Number and distribution of lymphocytes in man. A critical analysis. Klin Wochenschrift 52: 511–515.PubMed ID94141, 4853392
Comments "The combinatorial association of such stochastically generated light and heavy chains has the potential to generate many orders of magnitude more diversity than can be uniquely displayed on the 10^11 B-cells in a single individual’s lymphocyte population (primary sources)"
Entered by azim58
ID 110381