Estimated number of mRNA molecules in Th2 cells

Range ~1,000 molecules per IL-4-expressing cell
Organism Mouse Mus musculus
Reference Mariani, L., Schulz, E. G., Lexberg, M. H., Helmstetter, C., Radbruch, A., Löhning, M., & Höfer, T. (2010). Short-term memory in gene induction reveals the regulatory principle behind stochastic IL-4 expression. Molecular systems biology, 6(1). p.3 right column bottom paragraphPubMed ID20393579
Method Abstract: "Here, [researchers] study the interleukin-4 gene (il4) in T-helper lymphocytes, combining mathematical modeling with the experimental quantification of expression variability and critical parameters."
Comments P.3 right column bottom paragraph: "With a realistic transcription rate in the order of 1/s (Alberts et al, 2002), [researchers] estimated the mean number of mRNA molecules (<mRNA>) to lie in the range of ~10^3 per IL-4-expressing cell."
Entered by mar.esther23
ID 110174