Concentration in which protecting osmolytes accumulate without interfering with protein function or metabolic activities
| Range | >0.4 M |
|---|---|
| Organism | bacteria |
| Reference | Borwankar T, Röthlein C, Zhang G, Techen A, Dosche C, Ignatova Z. Natural osmolytes remodel the aggregation pathway of mutant huntingtin exon 1. Biochemistry. 2011 Mar 29 50(12):2048-60. doi: 10.1021/bi1018368. p.2048 right column top paragraphPubMed ID21332223 |
| Primary Source | Cayley, S., and Record, M. T., Jr. (2003) Roles of cytoplasmic osmolytes, water, and crowding in the response of Escherichia coli to osmotic stress: biophysical basis of osmoprotection by glycine betaine. Biochemistry 42, 12596–12609. AND Koo, S. P., Higgins, C. F., and Booth, I. R. (1991) Regulation of compatible solute accumulation in Salmonella typhimurium: evidence for a glycine betaine efflux system. J. Gen. Microbiol. 137, 2617–2625.PubMed ID14580206, 1783908 |
| Comments | "Protecting osmolytes can be either synthesized endogenously or taken up from the external cellular milieu through transporters (7) and accumulate in cells at a high concentration (>0.4M)(primary sources) without interfering with protein function or metabolic activities.(4)" |
| Entered by | Uri M |
| ID | 109635 |