Time scales for half of the cells to respond to switching from noninducing medium (raffinose) to galactose

Range Wildtype 1.60: mutant 2.72 hours
Organism Budding yeast Saccharomyces cerevisiae
Reference Ramsey SA, Smith JJ, Orrell D, Marelli M, Petersen TW, de Atauri P, Bolouri H, Aitchison JD. Dual feedback loops in the GAL regulon suppress cellular heterogeneity in yeast. Nat Genet. 2006 Sep38(9):1082-7 p.1083 right column 2nd paragraphPubMed ID16936734
Method "[Researchers] simulated and measured experimentally the time courses of the reporter responses in cells switched from noninducing medium (raffinose) to galactose."
Comments "The fluorescence histograms from the time-course experiment (Fig. 3) demonstrate a transiently bimodal distribution of the response in the double-loop-knockout and a uniform rate of response in wild-type cells...[researchers] estimated the time scales for half of the cells to respond as 1.60 h for the wild-type and 2.72 h for the mutant."
Entered by Uri M
ID 109588