Gibbs energy change of denaturation at 25°C

Range Lysozyme 16: cytochrome c 8 kcal/mol
Organism vertebrates
Reference Anjum F, Rishi V, Ahmad F. Compatibility of osmolytes with Gibbs energy of stabilization of proteins. Biochim Biophys Acta. 2000 Jan 3 1476(1):75-84. p.76 left column top paragraphPubMed ID10606769
Primary Source Privalov PL. Stability of proteins: small globular proteins. Adv Protein Chem. 1979 33: 167-241.PubMed ID44431
Comments "Tm (denaturation transition temperature) is not a measure of ?GD°. For example, lysozyme and cytochrome c have the same Tm of 80°C, but ?GD° values are 16 and 8 kcal/mol, respectively [primary source]." Hen lysozyme, horse cytochrome c
Entered by Uri M
ID 109551