ADP-binding site cellular concentration

Range ~0.14 mM
Organism Rat Rattus norvegicus
Reference Berg J, Hung YP, Yellen G. A genetically encoded fluorescent reporter of ATP:ADP ratio. Nat Methods. 2009 Feb6(2):161-6. doi: 10.1038/nmeth.1288. p.165 left column 2nd paragraphPubMed ID19122669
Primary Source Mörikofer-Zwez S, Walter P. Binding of ADP to rat liver cytosolic proteins and its influence on the ratio of free ATP/free ADP. Biochem J. 1989 Apr 1 259(1):117-24.PubMed ID2497727
Comments "The effect of such ADP-binding may be substantial for cells in a high energy state, but energy depletion (below a total ATP:ADP of ~7 to 30) should rapidly saturate the ADP-binding sites (whose cellular concentration is estimated to be ~0.14 mM (primary source)) and produce much lower free ATP:ADP ratios, closer to the estimates for total ATP:ADP ratio."
Entered by Uri M
ID 109312