Reduction of the energies of transmembrane ionic diffusion by ion channels

Range From 250 to 20 kJ/mol
Organism Generic
Reference Latorre R, Miller C. Conduction and selectivity in potassium channels. J Membr Biol. 1983 71(1-2):11-30. p.11 left column bottom paragraphPubMed ID6300405
Primary Source Frankenhaeuser B, Moore LE. The effect of temperature on the sodium and potassium permeability changes in myelinated nerve fibers of Xenopus laevis. J Physiol. 1963 Nov169: 431-7.PubMed ID14079679
Comments "Ion channels are integral membrane proteins spanning the lipid bilayer and necessarily communicating with both aqueous phases. Conceptually they may be considered as enzymes, in that they reduce the energies of transmembrane ionic diffusion from the 250 kJ/mol above to values in the range of 20 kJ/mol [primary source] - a rate enhancement of about 10^39"
Entered by Uri M
ID 109161