Growth rate of cells with one and five functional rRNA operons as percent of wildtype (6 rRNA operons)

Range Five functional rRNA operons 21: one functional rRNA operon 50 % lower growth rate than WT cells
Organism Bacteria Escherichia coli
Reference Tadmor AD, Tlusty T. A coarse-grained biophysical model of E. coli and its application to perturbation of the rRNA operon copy number. PLoS Comput Biol. 2008 May 2 4(4):e1000038. doi: 10.1371/journal.pcbi.1000038PubMed ID18437222
Primary Source Asai T, Condon C, Voulgaris J, Zaporojets D, Shen B, Al-Omar M, Squires C, Squires CL. Construction and initial characterization of Escherichia coli strains with few or no intact chromosomal rRNA operons. J Bacteriol. 1999 Jun181(12):3803-9.PubMed ID10368156
Comments "...experiments show that cells with fewer than six rRNA operons have a considerable lower growth rate [primary source] (c.f. Figure 2A presented later in the text). For example, cells with five functional rRNA operons have a 21% lower growth rate than WT cells, while cells with only one functional rRNA operon have a 50% lower growth rate than WT cells [primary source]."
Entered by Uri M
ID 109078