Total zinc quota of mammalian cells in culture

Value 0.4 fmol per cell
Organism Mammalian tissue culture cell
Reference Outten CE, O'Halloran TV. Femtomolar sensitivity of metalloregulatory proteins controlling zinc homeostasis. Science. 2001 Jun 29 292(5526):2488-92. p.2491 middle column top paragraphPubMed ID11397910
Primary Source Palmiter RD, Findley SD. Cloning and functional characterization of a mammalian zinc transporter that confers resistance to zinc. EMBO J. 1995 Feb 15 14(4):639-49. AND Suhy DA, Simon KD, Linzer DI, O'Halloran TV. Metallothionein is part of a zinc-scavenging mechanism for cell survival under conditions of extreme zinc deprivation. J Biol Chem. 1999 Apr 2 274(14):9183-92.PubMed ID7882967, 10092590
Comments "Mammalian cells in culture maintain a total zinc quota within a narrow range around 0.4 fmol per cell, corresponding to a total cellular Zn(II) concentration in the millimolar range (primary sources)."
Entered by Uri M
ID 108832