Infectious dose of E. coli enabled by three acid resistance (AR) systems

Range 10 to 100 Bacteria
Organism Bacteria Escherichia coli
Reference Ma Z, Gong S, Richard H, Tucker DL, Conway T, Foster JW. GadE (YhiE) activates glutamate decarboxylase-dependent acid resistance in Escherichia coli K-12. Mol Microbiol. 2003 Sep49(5):1309-20. p.1309 right column 2nd paragraphPubMed ID12940989
Primary Source Giannella RA, Broitman SA, Zamcheck N. Gastric acid barrier to ingested microorganisms in man: studies in vivo and in vitro. Gut. 1972 Apr13(4):251-6. AND Giannella RA, Broitman SA, Zamcheck N. Influence of gastric acidity on bacterial and parasitic enteric infections. A perspective. Ann Intern Med. 1973 Feb78(2):271-6. AND Peterson WL, Mackowiak PA, Barnett CC, Marling-Cason M, Haley ML. The human gastric bactericidal barrier: mechanisms of action, relative antibacterial activity, and dietary influences. J Infect Dis. 1989 May159(5):979-83.PubMed ID4556018, 4567180, 2651535
Comments "...pathogenic as well as commensal strains of Escherichia coli are exceptionally well adapted to survive extremely acidic pH even at low cell numbers. E. coli achieves this through three acid resistance (AR) systems...These systems enable an infectious dose as low as 10 to 100 organisms (primary sources)."
Entered by Uri M
ID 108576