| Value |
0.285
kcal/mol
|
| Organism |
Bacteria Escherichia coli |
| Reference |
McGuffee SR, Elcock AH. Diffusion, crowding & protein stability in a dynamic molecular model of the bacterial cytoplasm. PLoS Comput Biol. 2010 Mar 5 6(3):e1000694. p.2 left column bottom paragraphPubMed ID20221255
|
| Comments |
"A more realistic model of macromolecular interactions would allow favorable short-range attractions to occur between exposed hydrophobic atoms and one simple way of approximating such interactions is to use a Lennard-Jones potential, with the well-depth of the potential, e link being treated as an adjustable parameter (see Methods)....The best agreement with experiment is obtained with e= 0.285 kcal/mol: at this value of e the computed value of DL trans – which is ~10% of its value at infinite dilution – is within the experimental error of all in vivo estimates [15–18] including a very recent report for diffusion in cells growing in minimal media[18]." |
| Entered by |
Uri M |
| ID |
108460 |