Contribution of integral membrane proteins to total protein mass in HeLa cell

Value 7.6 %
Organism Human Homo sapiens
Reference Nagaraj N, Wisniewski JR, Geiger T, Cox J, Kircher M, Kelso J, Pääbo S, Mann M. Deep proteome and transcriptome mapping of a human cancer cell line. Mol Syst Biol. 2011 Nov 8 7: 548. doi: 10.1038/msb.2011.81. p.4 right column 2nd paragraphPubMed ID22068331
Method Online liquid chromatography coupled to high-resolution MS (mass spectrometry) and MS/MS
Comments "...integral membrane proteins account for 25% of the genome but contribute much less to the transcriptome and the proteome (7.6% of total protein mass). This presumably reflects the often cell type specific functions of these proteins (Lundberg et al, 2010 Ramskold et al, 2009)."
Entered by Uri M
ID 108432