| Range |
2e-8 to 4e-8 Mutations/site/generation
|
| Organism |
Human Homo sapiens |
| Reference |
Jianbin Wang, H. Christina Fan, Barry Behr and Stephen R. Quake Genome-wide Single-Cell Analysis of Recombination Activity and De Novo Mutation Rates in Human Sperm, Cell 150, 402–412, July 20, 2012 p.408 right column bottom paragraphPubMed ID22817899
|
| Method |
P.403 left column 2nd paragraph: "[Researchers] collected a sperm sample from a 40-year-old Caucasian individual (P0) whose genome has been sequenced (Pushkarev et al., 2009), clinically annotated (Ashley et al., 2010), and haplotype phased (Fan et al., 2011)." |
| Comments |
P.408 right column bottom paragraph: "P0’s mutation rate (2–4×10^-8) is higher than that obtained from genome-sequenced pedigree data (~1×10^-8) (Conrad et al., 2011), but it is consistent with evolutionary studies, which have revealed ~4–5× more mutations in male than in female,
possibly due to the larger number of germline cell divisions in male (Crow, 2000 Makova and Li, 2002)." |
| Entered by |
Uri M |
| ID |
108040 |