Preferred nucleosome linker lengths

Range 10.41n+4.6 or 10.47n+5.5 bp
Organism Budding yeast Saccharomyces cerevisiae
Reference Brogaard K, Xi L, Wang JP, Widom J. A map of nucleosome positions in yeast at base-pair resolution. Nature. 2012 Jun 3. doi: 10.1038/nature11142. p.499 right column 3rd paragraphPubMed ID22722846
Method Researchers developed a new, genome-wide mapping approach that directly determines nucleosome centre positions with single-base-pair resolution. It derives from earlier work in which localized hydroxyl radicals were used to map reconstituted mononucleosomes centre positions
Comments If researchers add 1 or 2 bp uniformly to each linker length to account for over-stretching of nucleosome DNAs, the linker length will follow a form of 10.41n+4.6 bp or 10.47n+5.5 bp (for integer n) respectively by Fourier analysis (for linker lengths=60 bp).
Entered by Uri M
ID 107880