Turnover of gastrointestinal cells

Range 3 to 4 enterocytes, goblet cells and enteroendocrine: ~21 Paneth cells Days
Organism Human Homo sapiens
Reference Li HJ, Ray SK, Singh NK, Johnston B, Leiter AB. Basic helix-loop-helix transcription factors and enteroendocrine cell differentiation. Diabetes Obes Metab. 2011 Oct13 Suppl 1:5-12. doi: 10.1111/j.1463-1326.2011.01438.x. p.6 left column 2nd paragraphPubMed ID21824251
Primary Source Cheng H, Leblond CP. Origin, differentiation and renewal of the four main epithelial cell types in the mouse small intestine. V. Unitarian Theory of the origin of the four epithelial cell types. Am J Anat. 1974 Dec141(4):537-61.PubMed ID4440635
Method Cell labelling kinetics
Comments "Cell labelling kinetics indicated that enterocytes, goblet cells and enteroendocrine cells differentiated as cells migrate up the crypt–villus axis turning over every 3–4 days, whereas Paneth cells migrated downwards to the crypt base with a much slower turnover of approximately 21 days (primary source)."
Entered by Uri M
ID 107812