Fraction of the DSB repair events in mitotic cells that result in a crossover

Range ~10 to 15 %
Organism Budding yeast Saccharomyces cerevisiae
Reference Agmon N, Yovel M, Harari Y, Liefshitz B, Kupiec M. The role of Holliday junction resolvases in the repair of spontaneous and induced DNA damage. Nucleic Acids Res. 2011 Sep 1 39(16):7009-19 p.7015 right column 2nd and bottom paragraphsPubMed ID21609961
Primary Source Inbar,O., Liefshitz,B., Bitan,G. and Kupiec,M. (2000) The relationship between homology length and crossing over during the repair of a broken chromosome. J. Biol. Chem., 275, 30833–30838. AND Borts,R.H. and Haber,J.E. (1987) Meiotic recombination in yeast: alteration by multiple heterozygosities. Science, 237, 1459–1465 AND Lee,P.S., Greenwell,P.W., Dominska,M., Gawel,M., Hamilton,M. and Petes,T.D. (2009) A fine-structure map of spontaneous mitotic crossovers in the yeast Saccharomyces cerevisiae. PLoS Genet., 5, e1000410 AND Bzymek,M., Thayer,N.H., Oh,S.D., Kleckner,N. and Hunter,N. (2010) Double Holliday junctions are intermediates of DNA break repair. Nature, 464, 937–941.PubMed ID10924495, 2820060, 19282969, 20348905
Comments DSB=Double Strand Breaks
Entered by Uri M
ID 107333