Periodicity of sodium in cerebrospinal fluid (CSF)

Range 12 hours and 1.65 hours Hours
Organism Human Homo sapiens
Reference Harrington MG et al., Cerebrospinal fluid sodium rhythms. Cerebrospinal Fluid Res. 2010 Jan 20 7: 3. p.1 3rd paragraph and p.4 right column 2nd paragraph and p.5 left column top paragraphPubMed ID20205754
Method P.2 right column bottom paragraph: "Sodium and potassium cations were calibrated (and continuously verified) with NIST-certified standard mixtures (SPEX CertiPrep, Metuchen, NJ, USA)."
Comments P.1 3rd paragraph: "The distribution of sodium varied much more than potassium, and there were statistically significant rhythms at 12 and 1.65 h periods." P.4 right column 2nd paragraph: "Data from 144 samples per subject over 24 h allows rhythms at 20 min or greater to be detected. The principal rhythm with a 12-h period is visible in Figures 4 & 5. [Investigators] have less confidence in the 24-h period, since this involved the entire time of [their] sampling. This would require further testing in a longer duration study. [They] did not confidently identify the other significant period at 1.65 h (100 min) in the raw data ([they] were not looking for it), but it is significant in all the spectral analyses (Figure 6 and Additional Files 1 and 2). The primary source of sodium is dietary, but since the two meal times of these participants did not coincide with the principal 12- or 1.6-h cycles, their diet is not likely to be responsible for these rhythms."
Entered by Uri M
ID 106946