| Value |
2.5e-3
mutation/genome/replication
Range: Table - link mutation/genome/replication
|
| Organism |
Bacteria Escherichia coli |
| Reference |
Drake JW, Charlesworth B, Charlesworth D, Crow JF. Rates of spontaneous mutation. Genetics. 1998 Apr148(4):1667-86. p.1670 table 4PubMed ID9560386
|
| Primary Source |
Drake JW, A constant rate of spontaneous mutation in DNA-based microbes.Proc Natl Acad Sci U S A. 1991 Aug 15 88(16):7160-4 Table 1 - link PubMed ID1831267
|
| Method |
(primary source:) Many replicate cultures are grown from small mutant-free inocula until roughly half have experienced a mutation, and the cultures are then scored for average population size and for mutants. |
| Comments |
"Mutation rates in DNA-based microbes: Rates of spontaneous mutation in this class of organisms were last surveyed in Drake (1991) and are summarized in Table 4 using a few updated values for genome sizes. Unlike the experimental and theoretical limits to the accuracy of the RNA-virus values, the DNA-microbe values were determined in well-studied systems using robust calculations, and the individual values are likely to be accurate to within two-fold. Table 4 shows that µb and G vary inversely and smoothly over nearly four orders of magnitude while µg remains constant. Given the paucity of general, constant values in evolutionary processes, this particular constant is strikingly robust." For description of parameters see link |
| Entered by |
Uri M |
| ID |
106748 |