Duration of histone modifications (see comments section)

Range Acetylation minutes: phosphorylation several hours: methylation days
Organism Eukaryotes
Reference Hnilicová J, Stanek D. Where splicing joins chromatin. Nucleus. 2011 May2(3):182-188. p.182 left column 2nd paragraph p.183 right column top paragraphPubMed ID21818411
Primary Source Gunderson FQ, Merkhofer EC, Johnson TL. Dynamic histone acetylation is critical for cotranscriptional spliceosome assembly and spliceosomal rearrangements. Proc Natl Acad Sci U S A. 2011 Feb 1 108(5):2004-9PubMed ID21245291
Comments The modifications differ substantially in their turnover: the addition and removal of acetylation is rapid and most acetyl residues are exchanged within minutes, phosphorylations can last up to several hours and methylations, the most stable ones, can be present even for days (primary source).
Entered by Uri M
ID 106733