Effective population size

Value 4135 Organisms Range: 3332 to 5107 Organisms
Organism Measels virus
Reference Bedford T, Cobey S, Pascual M. Strength and tempo of selection revealed in viral gene genealogies. BMC Evol Biol. 2011 Jul 25 11(1):220 doi:10.1186/1471-2148-11-220 p.4 left column top paragraphPubMed ID21787390
Comments P.2 right column bottom paragraph to p.4 left column top paragraph: "From sequence data alone, it is impossible to independently identify Ne [effective population size] and τ [generation time], only their product Neτ can be estimated. [Investigators] fit a phylogenetic model incorporating the coalescent process to sequence data to estimate genealogical trees and coalescent parameters for influenza and measles virus (Figure 1). In this case, [they] estimate Neτ for HA [hemagglutinin] of influenza A (H3N2) at 7.2 years (95% credible interval 6.2-8.4) and Neτ for measles at 124.6 years (100.4-153.9). These estimates give quantification to the visual differences apparent in genealogical trees. [They] arrive at independent estimates of τ via experimental and epidemiological data on the duration of infection, which [they] take as 5 days for influenza (τ = 0.014 years per generation) [primary source 17] and 11 days for measles (τ = 0.030 years per generation) [primary source 14]. [Their] basic results do not depend on these exact estimates. Dividing by τ yields estimates of Ne = 526 (451-611) for influenza and Ne = 4135 (3332-5107) for measles."
Entered by Uri M
ID 106587