| Value |
85
%
|
| Organism |
Bacteria Escherichia coli |
| Reference |
Scott M, Gunderson CW, Mateescu EM, Zhang Z, Hwa T. Interdependence of cell growth and gene expression: origins and consequences. Science. 2010 Nov 19 330(6007):1099-102. p.1099 middle columnPubMed ID21097934
|
| Primary Source |
10) H. Bremer, P. P. Dennis, in Escherichia coli and Salmonella, F. C. Neidhardt, Ed. (ASM Press, Washington, DC, 1996), pp. 1553–1569. AND (11) O. Maaløe, in Biological Regulation and Development, R. F. Goldberger, Ed. (Plenum, New York, 1979), pp. 487–542. |
| Comments |
"It is well known that the macromolecular composition (e.g., the mass fractions of protein, RNA, and DNA) of bacterial cells under exponential growth depends on the growth medium predominantly through the growth rate allowed by the nutritional content of the medium (refs 9, 10). Such growth rate dependencies inevitably affect the expression of individual genes (refs 4, 11) because protein synthesis is directly dependent on the cell’s ribosome content. The latter is reflected by the RNA/protein ratio. In Escherichia coli, most of the RNA (~85%) is rRNA folded in ribosomes (primary sources 10, 11)." Note-according to comments section of BNID 100067 (from the 1st primary source above) the rRNA fraction is 77.5% |
| Entered by |
Uri M |
| ID |
106421 |