Reduction in membrane binding of myristoylated protein by each phosphorylation event

Value 10 fold
Organism Generic
Reference McLaughlin S, Aderem A. The myristoyl-electrostatic switch: a modulator of reversible protein-membrane interactions. Trends Biochem Sci. 1995 Jul20(7):272-6. p.274 left column 1st paragraphPubMed ID7667880
Primary Source C. Buser, C. Sigal, M. Resh and S. McLaughlin, unpublished
Comments McLaughlin's observations strongly suggest that the binding is due to nonspecific electrostatic attraction and that phosphorylation reduces the affinity by reducing the net positive charge of the peptide. See BNID 105724
Entered by Uri M
ID 105721