Number of protein-coding genes

Value 4225 Genes
Organism Bacteria Escherichia coli
Reference Hu P. et al., Global functional atlas of Escherichia coli encompassing previously uncharacterized proteins. PLoS Biol. 2009 Apr 28 7(4):e96. doi: 10.1371/journal.pbio.1000096. abstract & p.0930 right column top paragraphPubMed ID19402753
Method Extracted from UniProt: the Universal Protein knowledgebase at link Note-as of May 1st 2015 the value for E. coli k-12 is 4,305 proteins
Comments Abstract: "One-third of the 4,225 protein-coding genes of Escherichia coli K-12 remain functionally unannotated (orphans). Many map to distant clades such as Archaea, suggesting involvement in basic prokaryotic traits, whereas others appear restricted to E. coli, including pathogenic strains." P.930 right column top paragraph: "To evaluate the degree to which the physiological functions of the 4,225 putative protein-coding sequences of E. coli K-12 are characterized presently, [researchers] examined the scope of literature reference records curated in the UniProt annotation system [ref 23 PMID 14681372]." For total Gene number of 4606 see BNID 100272. For 4,285 proteins see PMID 15911532 p.1205 right column top paragraph
Entered by Uri M
ID 105443