Duration between synthesis of MHC I W6/32 molecule and its appearance on cell surface
| Value | 1 Hour |
|---|---|
| Organism | Human Homo sapiens |
| Reference | Carreno BM, Hansen TH. Exogenous peptide ligand influences the expression and half-life of free HLA class I heavy chains ubiquitously detected at the cell surface. Eur J Immunol. 1994 Jun24 (6):1285-92.PubMed ID8206088 |
| Comments | Within a few minutes of synthesis, free HLA heavy chains (HClO+) become fi2m-associated and gain recognition by mAb specific for the alla2 region in its native conformation (e.g. mAb W6/32). Shortly thereafter, high mannose carrying W6/32-reactive molecules are transported from the endoplasmic reticulum (ER) to the Golgi, where their carbohydrate side chains undergoes oligosaccharide maturation. Mature W6/32 species are detected at the cell surface within 1 h of synthesis |
| Entered by | Uri M |
| ID | 104754 |