Speed of viral particles in myosin-directed actin-based transport

Value 0.1 µm/sec
Organism Unspecified
Reference Arhel N, Genovesio A, Kim KA, Miko S, Perret E, Olivo-Marin JC, Shorte S, Charneau P. Quantitative four-dimensional tracking of cytoplasmic and nuclear HIV-1 complexes. Nat Methods. 2006 Oct3(10):817-24 p.817 right column 2nd paragraphPubMed ID16990814
Primary Source Lakadamyali M, Rust MJ, Babcock HP, Zhuang X. Visualizing infection of individual influenza viruses. Proc Natl Acad Sci U S A. 2003 Aug 5 100(16):9280-5 AND Smith DA, Simmons RM. Models of motor-assisted transport of intracellular particles. Biophys J. 2001 Jan80(1):45-68. AND Apodaca G. Endocytic traffic in polarized epithelial cells: role of the actin and microtubule cytoskeleton. Traffic. 2001 Mar2(3):149-59.PubMed ID12883000, 11159382, 11260520
Method Time lapse analysis
Comments Time-lapse analyses of microtubule-dependent movements of viral particles such as vaccinia virus (ref 13), adenovirus (ref 1,14) or influenza virus (ref 4) revealed maximum speeds ranging from approx 0.2 to 2 µm/sec See BNID 104712. Myosin-directed actin-based transport, which is distinct from the propulsion on actin filaments described for some intracellular bacteria and vaccinia virus, tends to be substantially slower than microtubule-directed transport (approx 0.1 µm/sec) and covers shorter distances (primary sources).
Entered by Uri M
ID 104713