Table - link
||Mammalian tissue culture cell
||Lee JI, Nian H, Cooper AJ, Sinha R, Dai J, Bisson WH, Dashwood RH, Pinto JT. Alpha-keto acid metabolites of naturally occurring organoselenium compounds as inhibitors of histone deacetylase in human prostate cancer cells. Cancer Prev Res (Phila Pa). 2009 Jul2(7):683-93. p.688 table 1PubMed ID19584079
||In a cell-free system, glutamine transaminase K (GTK) and L-amino acid oxidase convert Methyl-L-selenocysteine (MSC) to the corresponding alpha-keto acid, beta-methylselenopyruvate (MSP), and L-amino acid oxidase converts selenomethionine to its corresponding alpha-keto acid, alpha-keto-gamma-methylselenobutyrate (KMSB). Researchers examined androgen-responsive LNCaP cells and androgen-independent LNCaP C4-2, PC-3, and DU145 cells and found that these human prostate cancer cells exhibit endogenous GTK activities. In the corresponding cytosolic extracts, the metabolism of MSC was accompanied by the concomitant formation of beta-methylselenopyruvate (MSP).
||Specific activity measured by rate of phenolpyruvate formed.