Change in Gibbs free energy in hydrolysis of Succynil CoA

Value -44.8 kJ/mol Range: Table - link kJ/mol
Organism Unspecified
Reference Thauer RK, Jungermann K, Decker K. Energy conservation in chemotrophic anaerobic bacteria.Bacteriol Rev. 1977 Mar41(1):100-80. p.108 table 4PubMed ID860983
Primary Source [620] Stadtman, E. R. 1973. Adenylyl transfer reactions, p. 1-49. In P. D. Boyer (ed.), The enzymes, vol. 8, 3rd ed. Academic Press Inc., New York.
Comments P.107 left column bottom paragraph: ""Energy-rich" compounds are characterized by their free energy of hydrolysis ("group transfer potential") (ΔG0'), which lies in the range of -5 to -15 kcal/mol (-20.9 to -62.8 kJ/mol) and by the fact that they exist in an enzymatic equilibrium with the ATP system. These "energy-rich" compounds are acid anhydrides or thioesters (Table 4), i.e., derivatives of carboxylic acids which represent the highest oxidation level of the carbon atom in organic compounds." Table gives gibbs free energy of hydrolysis of energy rich compounds involved in Substrate-level phosphorylation (SLP). SLP is a type of chemical reaction that results in the formation and creation of adenosine triphosphate (ATP) by the direct transfer and donation of a phosphate group to adenosine diphosphate (ADP) from a reactive intermediate. In cells, it occurs primarily and firstly in the cytoplasm (in glycolysis) under both aerobic and anaerobic conditions. Succynil CoA undergoes SLP in the citric acid cycle
Entered by Uri M
ID 104431