Replication rate of PolC

Value 480 nucleotides/sec
Organism Bacteria Staphylococcus aureus
Reference Klemperer N, Zhang D, Skangalis M, O'Donnell M. Cross-utilization of the beta sliding clamp by replicative polymerases of evolutionary divergent organisms. J Biol Chem. 2000 Aug 25275(34):26136-43PubMed ID10851235
Method This study examines replicase components for their ability to be switched between Gram-positive and Gram-negative organisms.
Comments S. aureus PolC, in complex with S. aureus beta , can travel at a rate of at least 480 nucleotides per s, close to the 750 nucleotides per s speed of E. coli DNA polymerase III holoenzyme.
Entered by Uri M
ID 104391