| Range |
5.1X3.5X2.2 nm
|
| Organism |
Human Homo sapiens |
| Reference |
Nauman JV, Campbell PG, Lanni F, Anderson JL. Diffusion of insulin-like growth factor-I and ribonuclease through fibrin gels. Biophys J. 2007 Jun 1592(12):4444-50.PubMed ID17400703
|
| Primary Source |
Vajdos FF, Ultsch M, Schaffer ML, Deshayes KD, Liu J, Skelton NJ, de Vos AM. Crystal structure of human insulin-like growth factor-1: detergent binding inhibits binding protein interactions. Biochemistry. 2001 Sep 1840(37):11022-9PubMed ID11551198
|
| Method |
Using crystallographic coordinates for IGF-I (Protein Data Bank accession number 1imx (29)) and RasMol software (30), external dimensions of the molecule were estimated by rotating the space-filling structure to orientations showing the maximum and minimum projected widths, then selecting pairs of atoms to obtain outer dimensions. By this procedure, major axes of 51.16, 34.52, and 21.47 Å were determined. |
| Comments |
The IGF monomer consists of a globular domain with two small diametrically opposed projections which define the long axis. The external dimensions of the globular domain only were taken as 31.28, 34.52, and 21.47 Å. |
| Entered by |
Uri M |
| ID |
104033 |