Constant of repressor binding to auxiliary operator located upstream of the Lac promoter

Value 0.05 nM
Organism Bacteria Escherichia coli
Reference Bintu L, Buchler NE, Garcia HG, Gerland U, Hwa T, Kondev J, Kuhlman T, Phillips R. Transcriptional regulation by the numbers: applications. Curr Opin Genet Dev. 2005 Apr15(2):125-35PubMed ID15797195
Primary Source Oehler S, Amouyal M, Kolkhof P, von Wilcken-Bergmann B, Müller-Hill B. Quality and position of the three lac operators of E. coli define efficiency of repression. EMBO J. 1994 Jul 1513(14):3348-55PubMed ID8045263
Method Researchers investigated cooperative repression of the Escherichia coli lac operon by systematic conversion of its three natural operators (O1, O2 and O3) on the chromosome.
Entered by Uri M
ID 103603