Volume of alveolar macrophage cell

Value 4990 µm^3 Range: ±174 µm^3
Organism Human Homo sapiens
Reference Krombach F, Münzing S, Allmeling AM, Gerlach JT, Behr J, Dörger M. Cell size of alveolar macrophages: an interspecies comparison. Environ Health Perspect. 1997 Sep105 Suppl 5:1261-3. abstract & p.1262 table 2PubMed ID9400735
Method Abstract: "Resident AM [alveolar macrophage] from CD rats, Syrian golden hamsters, cynomolgus monkeys, and nonsmoking, healthy human volunteers were harvested by standard bronchoalveolar lavage procedures. Morphometric analysis of alveolar macrophage was performed using a flow cytometer that generates volume signals based on the Coulter-type measurement of electrical resistance."
Comments P.1262 middle column bottom paragraph: "Table 2 summarizes the morphometric data obtained by selective Coulter-type flow cytometric analysis of unfixed cells in suspension. The cell sizes of hamster and rat AM were not statistically different from each other. Comparatively, the AM from monkeys and nonsmoking, healthy human volunteers were significantly larger (p<0.05) than those from rats and hamsters. The AM from human volunteers were significantly larger (p<0.05) than those from all other species studied, corresponding to a roughly 4-fold larger cell volume of human AM compared to hamster and rat AM." For additional mammalian cell volumes see BNID 101711, 101666, 103180
Entered by Uri M
ID 103566