Number of calcium ions required to release neurotransmitter vesicle at presynaptic cleft

Range 200-13,000 Calcium ions/released vesicle
Organism vertebrates
Reference Laughlin SB, de Ruyter van Steveninck RR, Anderson JC. The metabolic cost of neural information. Nat Neurosci. 1998 May1(1):36-41 p.38 right column 2nd paragraphPubMed ID10195106
Primary Source Borst, J.G.G. & Sakmann, B.Calcium influx and transmitter release in a fast CNS synapse. Nature 383, 431-434 (1996) p.431 right column bottom paragraph link PubMed ID8837774
Comments P.38 right column 2nd paragraph:"Using experimental data, [researchers] estimate that the costs of neurotransmitter uptake and vesicle refilling total less than 10% of the postsynaptic current (see Methods). Estimates of presynaptic calcium flux vary from 200 to 1.3×10^4 ions per vesicle discharged [primary source]." See link in primary source section.
Entered by Uri M
ID 103549