Contribution of hydrogen bonding to selectivity of DNA polymerase

Value <=40 Fold
Organism Unspecified
Reference Hani S. Zaher and Rachel Green, Fidelity at the Molecular Level: Lessons from Protein Synthesis. Cell Volume 136, Issue 4, 20 February 2009, Pages 746-762PubMed ID19239893
Primary Source Kunkel and Bebenek, 2000 T.A. Kunkel and K. Bebenek, DNA replication fidelity, Annu. Rev. Biochem. 69 (2000), pp. 497–529.PubMed ID10966467
Comments The energetics of hydrogen bonding could contribute 40-fold at most to the selectivity of DNA polymerases, and most of the selectivity must instead result from correct recognition of the geometry of a Watson-Crick base-pair
Entered by Uri M
ID 103482