Half time (t1/2) for delivery of insulin to the lysosomes of renal proximal tubule

Value 8.5 min Range: ±1 min
Organism Rabbit
Reference Nielsen S. Time course and kinetics of proximal tubular processing of insulin. Am J Physiol. 1992 May262(5 Pt 2):F817PubMed ID1590426
Method Proximal tubular segments (S2) of rabbit kidney were perfused with 125 insulin (from pig) at low concentrations for as long as 90 min.From proximal tubules perfused with 125I-insulin for 30 min and chased for 60 min, a compartmental analysis revealed two compartments.
Comments This is the time insulin moved from endocytic vesicles to lysosomes
Entered by Uri M
ID 103362