Area on lipid bilayer occupied by phospholipid molecule

Value ~65 Å^2
Organism Rat Rattus norvegicus
Reference Takamori S et al., Molecular anatomy of a trafficking organelle. Cell. 2006 Nov 17 127(4):831-46. DOI: 10.1016/j.cell.2006.10.030 p.838 right column 3rd paragraphPubMed ID17110340
Primary Source Nagle JF, Tristram-Nagle S. Structure of lipid bilayers. Biochim Biophys Acta. 2000 Nov 10 1469(3):159-95.PubMed ID11063882
Comments P.838 right column 3rd paragraph: "The number of all phospholipid and cholesterol molecules per vesicle was calculated to be approximately 7000 and 5600, respectively, with hexosylceramides and gangliosides making only a relatively minor contribution (Table 2). Considering that a single phospholipid molecule occupies a space of approximately 65 Å^2 (0.65 nm^2) (primary source), 7000 phospholipids would build a planar bilayer of 4550 nm^2, i.e., 50% of the outer and inner surfaces of a vesicle possessing an outer diameter of 42 nm."
Entered by Uri M
ID 102781