Number of cholesterol molecules in synaptic vesicle

Value ~5600 unitless
Organism Rat Rattus norvegicus
Reference Takamori S et al., Molecular anatomy of a trafficking organelle. Cell. 2006 Nov 17 127(4):831-46. DOI: 10.1016/j.cell.2006.10.030 p.838 right column 3rd paragraphPubMed ID17110340
Method P.836 right column bottom paragraph: "To construct a molecular model of a prototypic SV, [investigators] first calculated the average copy number per vesicle of the proteins quantified above (see Figure 1) based on the known molecular mass, Avogadro's number, and the average protein content per vesicle (Table 2, see also Table S2)."
Comments P.838 right column 3rd paragraph: "The number of all phospholipid and cholesterol molecules per vesicle was calculated to be approximately 7000 and 5600, respectively, with hexosylceramides and gangliosides making only a relatively minor contribution (Table 2)." Note-p.839 table 2 gives value of 5,663 cholesterol molecules/vesicle
Entered by Uri M
ID 102780