size of pore across HIV TAT protein allowing passage through membrane

Value 3 nm
Organism HIV
Reference Vyas JM, Van der Veen AG, Ploegh HL. The known unknowns of antigen processing and presentation. Nat Rev Immunol. 2008 Aug8(8):607-18.PubMed ID18641646
Primary Source Herce HD, Garcia AE. Molecular dynamics simulations suggest a mechanism for translocation of the HIV-1 TAT peptide across lipid membranes.Proc Natl Acad Sci U S A. 2007 Dec 26104(52):pp. 20808PubMed ID18093956
Method Molecular dynamics simulations were performed to study the translocation mechanism of the protein transduction domain of the HIV-1 Tat across model membranes. The Tat peptides were placed in a periodically repeating box containing a preequilibrated lipid membrane composed of DOPC lipids and water molecules
Entered by Uri M
ID 102675