Survival time after last cell division of T cell not recognizing MHC molecules

Value <= days Range: ≤4 days
Organism Mouse Mus musculus
Reference Charles A. Janeway Jr., Paul Travers, Mark Walport, Mark J. Shlomchik, Immunobiology, 5th edition : the immune system in health and disease [ncbi- electronic resource] link section 7.20 p.262 2nd paragraph
Comments P.262 2nd paragraph: "Such experiments have also established the fate of T cells that fail positive selection. Rearranged receptor genes from a mature T cell specific for a peptide presented by a particular MHC molecule were introduced into a recipient mouse lacking that MHC molecule, and the fate of the thymocytes was investigated by staining with antibodies specific for the transgenic receptor. Antibodies to other molecules such as CD4 and CD8 were used at the same time to mark the stages of T-cell development. It was found that cells that fail to recognize the MHC molecules present on the thymic epithelium never progress further than the double-positive stage and die in the thymus within 3 or 4 days of their last division."
Entered by Uri M
ID 102643