Amount of complete (tetramer) haemoglobin in erythrocyte

Value 2.8e+8 molecules/cell
Organism Mouse Mus musculus
Reference Voon HP, Vadolas J. Controlling alpha-globin: a review of alpha-globin expression and its impact on beta-thalassemia. Haematologica. 2008 Dec93(12):1868-76. doi: 10.3324/haematol.13490. p. 1871 left column bottom paragraphPubMed ID18768527
Primary Source Anguita E, Hughes J, Heyworth C, Blobel GA, Wood WG, Higgs DR. Globin gene activation during haemopoiesis is driven by protein complexes nucleated by GATA-1 and GATA-2. EMBO J. 2004 Jul 21 23(14):2841-52 p. 12847 right column bottom paragraph (continuing next page)PubMed ID15215894
Comments The transcriptional process gives rise to an estimated 10,000-20,000 mature, stabilized transcripts which are utilized repeatedly to generate an estimated 280 million molecules of complete hemoglobin molecules per cell (ref citing primary source).
Entered by Uri M
ID 102292