||Reynolds JA, Gilbert DB, Tanford C. Empirical Correlation Between Hydrophobic Free Energy and Aqueous Cavity Surface Area. Proc Natl Acad Sci U S A. 1974 Aug71(8):2925-2927. abstract, p.2925 right column 3rd paragraph & p.2927 left column 5th paragraphPubMed ID16578715
||Calculated from equation : µ°W-µ°HC=RTln[X(HC)/X(W)] where X(HC) and X(W) are the equilibrium concentrations in mole fraction units in hydrocarbon and water, respectively, and µ°HC and µ°W are the corresponding standard chemical potentials. This equation developed into eq. 3 and graph plotted with chemical potential difference (left side of eq.) as ordinate and cavity surface area as abscissa (fig. 2). The slope is 20-25 cal/mol/Å^2. Based on empirical data.
||"The proportionality constant is 21-25
cal/mole per Å^2 for saturated aliphatic hydrocarbons and
=20 cal/mole per Å^2 for aromatic hydrocarbons."