Range: cv(9.16) Table - link 1/hour
||Bacteria Staphylococcus aureus
||Chung P, McNamara PJ, Campion JJ, Evans ME. Mechanism-based pharmacodynamic models of fluoroquinolone resistance in Staphylococcus aureus. Antimicrob Agents Chemother. 2006 Sep50(9):2957-65. free online article p. 2961 table 2PubMed ID16940088
||Researchers developed two novel pharmacodynamic models that assign mechanisms of action to fluoroquinolone antimicrobial agents (growth inhibition or death stimulation) and compared the abilities of these models and two other maximum effect models—our previously described net effect model (ref 5 in article) and the MIC-based model reported by Meagher and colleagues (ref 18 in article) to describe and predict the changes in bacterial population dynamics during in vitro system experiments where S. aureus was exposed to a series of simulated ciprofloxacin pharmacokinetic profiles (refs 4,5 in article).
||Values for bacterial growth in vitro are: for susceptible and resistant populations of both MRSA 8043 and MRSA 8043C0-1 0.99h^-1(9.16) and 0.66h^-1 (2.58), respectively. For susceptible and resistant populations of both MRSA 8282 and MRSA 8282C0-1, 0.93h^-1 (7.05) and 0.70h^-1 (2.84), respectively. In vitro. Growth rate of 0.99h^-1 corresponds to doubling time of 42min. See BNID 105553