Rate of DNA replication
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|Organism||Human Homo sapiens|
|Reference||Fangman WL, Brewer BJ. A question of time: replication origins of eukaryotic chromosomes. Cell. 1992 Oct 30 71(3):363-6PubMed ID1423601|
|Method||Replication fork speed of ~ 2000 base pairs/min=2000/60base pairs/sec=33 base pairs/sec|
|Comments||Article also gives info on distance between origins of replication: For a human cell, the approximately 3,000,000 kb genome is replicated in about 8 h. Since the rate at which replication forks plow through chromatin is no greater than ~2 kb/min, bidirectional origins would need to be spaced at roughly 2000 kb intervals to finish replication in the allotted time. For DNA Polymerase d synthesis rate of 87±5.7 sec^-1 see BNID 105486|
|Entered by||Uri M|