Results
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| Property | Organism | Value | Units | ID | Details |
|---|---|---|---|---|---|
| Number of distinct expressed p53 isoforms | Human Homo sapiens | 12 | Isoforms | 106631 | Khoury MP, Bourdon JC.... |
| Absolute abundance of p53 in cell | Human Homo sapiens | ~160,000 (21,000 to 195,700) | Copies/cell | 100420 | Ma L, Wagner J, Rice JJ... |
| p53 concentration in wildtype colorectal cancer cell SW620 | Human Homo sapiens | 0.64 (±0.015 Table - link) | nM | 106635 | Wang Y, Zhu X, Wu M, Xia N... |
| p53 concentration in wildtype liver cell L-02 | Human Homo sapiens | 2.87 (±0.043 Table - link) | nM | 106632 | Wang Y, Zhu X, Wu M, Xia N... |
| p53 concentration in wildtype endothelial cell ECV-304 | Human Homo sapiens | 1.03 (±0.013 Table - link) | nM | 106633 | Wang Y, Zhu X, Wu M, Xia N... |
| p53 concentration in wildtype liver cancer cell HepG-2 | Human Homo sapiens | 0.24 (±0.015 Table - link) | nM | 106634 | Wang Y, Zhu X, Wu M, Xia N... |
| Diffusion constant of p53 fused to GFP | Human Homo sapiens | 15.4 (±5.6 Table - link) | µm^2/sec | 103410 | Hinow P, Rogers CE, Barbieri... |
| Life time of p53 | Eukaryotes | 15 | Min | 106237 | Weinberg RA. The ret... |
| Fraction of patients diagnosed with cancer that have mutation in p53 gene | Human Homo sapiens | 50 | % | 105092 | Koshland DE Jr. Molecule... |
| Diffusion coefficient of p53 on elongated DNA | Human Homo sapiens | 3.01х10^5 Table - link | nm^2/sec | 107462 | DeSantis MC, Li JL, Wang... |
| Number of p53 transcription factor molecules per cell | Human Homo sapiens | 21,000 LB19 B-lymphoblastoid cell line: 160,000 MCF-7 breast carcinoma cell line | Molecules/cell | 106910 | Mark D. Biggin, Animal... |
| Fraction of of colitis-associated tumors in which allelic deletion of p53 was observed | Human Homo sapiens | 50-80 | % | 106629 | Ullman TA, Itzkowitz... |
| Diffusion constant of p53-GFP | Mammalian tissue culture cell | 15.4 (±5.6 Table - link) | µm^2/sec | 106693 | Hinow P, Rogers CE, Barbieri... |
| Number of annotated PTM [Post-Translational Modification] sites in the disordered N- and C-terminal transactivation domains of transcription factor and oncoprotein p53 | Human Homo sapiens | ∼20 | annotated PTM sites | 116291 | Theillet FX et al., ... |
| Fraction of lung cancers in which a mutation in p53 is found | Human Homo sapiens | >50 | % | 110653 | Cairns J. Somatic stem... |
| Fraction of females infected with human papilloma virus (HPV) | Human Homo sapiens | ages 19-25 >25%: over 35 years of age <5% | % | 117053 | O'Byrne KJ, Dalgleish... |
| Conditions developed by T-cell receptor β and p53 double-knockout mice | Mouse Mus musculus | 90% chronic inammation: 50-70% dysplasia: 70% adenocarcinoma | % | 106628 | Ullman TA, Itzkowitz... |
| Human optics | Human Homo sapiens | Table - link | N/A | 107893 | R. W. Rodieck, The first... |
| Fraction of mutations in human cancers that DNA replication errors (R) are responsible for | Human Homo sapiens | two thirds | N/A | 115304 | Tomasetti C, Li L, Vogelstein... |
| Upper bound of TF [Transcription Factor] coding genes in the human genome | Human Homo sapiens | 1,700 to 1,900 (1,391 manually curated sequence-specific DNA-binding transcription factors) | Transcription factor genes | 109201 | Vaquerizas JM, Kummerfeld SK... |