Results
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| Property | Organism | Value | Units | ID | Details |
|---|---|---|---|---|---|
| EGFR (epidermal growth factor receptor) levels (see comments section for normal cell types) | Mammals | normal cells 5,000 to 200,000: cancer cells ≤2––3×10^6 | EGFR/cell | 112720 | Sorkin A, Duex JE. Q... |
| Number of EGFR copies in a HeLa cell | Human Homo sapiens | 50000 (30000-80000 Table - link) | copies/cell | 104829 | Schoeberl B, Eichler-Jonsson... |
| Total number of EGFR (surface and intracellular) in PC12 cells | Rat Rattus norvegicus | 15000 (Table - link) | molecules/cell | 100899 | Brightman FA and Fell DA... |
| Number of EGFR [Epidermal Growth Factor Receptor] in hepatocyte | Rat Rattus norvegicus | in perfused liver 150,000: in vitro ~300,000 | molecules/cell | 112725 | Dunn WA, Hubbard AL.... |
| kcat of p38α (MAPK14) protein kinase with EGFR as substrate | Bacteria Escherichia coli | 31.6 (±1.1) | sec^-1 | 110568 | Zhang YY, Mei ZQ, Wu JW... |
| EGF [Epidermal Growth Factor] internalization and transit the early endosome in HMEC [Human Mammary Epithelial Cells] | Human Homo sapiens | t1/2 of EGF internalization ~5: transit the early endosome ≥20 | min | 112722 | Burke P, Schooler K,... |
| HER2 concentration (for cell types see comments section) | Human Homo sapiens | in mammary epithelial cells <10,000: in HB2 cells ~60,000 | molecules/cell | 112721 | Burke P, Schooler K,... |
| Turnover rate for RTK [Receptor Tyrosine Kinases] for cell types see comments section | Mammals | for colony stimulating factor 1 receptor (CSF-1R) <1hour: for EGFR 24hours | hours | 112723 | Goh LK, Sorkin A. Endocytosis... |
| Rate of receptor internalization in PC12 cells | Rat Rattus norvegicus | 0.7 (Table - link) | min^-1 | 100896 | Brightman FA and Fell DA... |
| Diameter of epidermal growth factor receptor/inhibitor complex | Human Homo sapiens | 6.168 | nm | 103209 | Stamos J, Sliwkowski MX... |
| Fraction of colorectal cancer cases that metastasize to the liver | Human Homo sapiens | 60 | % | 106160 | Geva R, Prenen H, Topal B... |
| Number of nicotinic acetylcholine receptors on surface of keratinocyte | Unspecified | 35000 | molecules/cell | 103769 | Grando SA, Horton RM... |
| Number of odorant receptor types | Mammals | 1000 | types | 109135 | Krieger J, Breer H. Olfactory... |
| Volume of hepatocyte | Rat Rattus norvegicus | ~7,000 | μm^3 | 104616 | Maryna Bondarava, Thesis:... |
| Number of EGF receptors per fetal lung cell | Rat Rattus norvegicus | 25500 | unitless | 101360 | Waters CM, Oberg KC,... |
| Kinetic parameters of the MAP Kinase cascade | Human Homo sapiens | Excel Table - link | N/A | 104830 | Schoeberl B, Eichler-Jonsson... |
| Number of DNA depurinations | Human Homo sapiens | 2,000-10,000 | depurinations/cell/day | 112975 | Lindahl T. Instability... |
| Fraction of hepatic stellate cells that express desmin | Rat Rattus norvegicus | 70-80% express desmin: 20-30% do not | % | 106561 | Geerts A. History, h... |
| Theoretical estimates relevant to epidermal organization | Mammals | Table - link | N/A | 109889 | Hoath SB, Leahy DG. The... |
| Diameter of late endosome in HeLa cell | Human Homo sapiens | 0.76 | µm | 104378 | Ganley IG, Carroll K... |